Nordale Road, a small street off of Chena Hot Springs Road was closed down as troopers investigated the incident.
Trooper have yet to release the names of the two victims. They are currently in the process of notifying next of kin.
The two fatalities were from each of two vehicles, a 1999 Ford Truck and a 2005 Kia Spectra. A third person was transported to the Fairbanks Memorial Hospital for treatment of injuries.